ITRI-126
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| Drug Name | ITRI-126 |
| Trade Name | |
| Synonyms | |
| Drug Descriptions |
ITRI-126 is an androgen receptor (AR) degrader containing an AR N-terminal binding region linked to a CRBN E3 ligase-binding moiety, which induces proteasomal degradation of full-length AR and ligand-binding domain truncated AR variants, potentially leading to tumor growth inhibition (PMID: 36893587). |
| DrugClasses | Hormone - Anti-androgens 57 |
| CAS Registry Number | NA |
| NCIT ID | NA |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Enzalutamide + ITRI-126 | Enzalutamide ITRI-126 | 0 | 0 |
| ITRI-126 | ITRI-126 | 0 | 0 |
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