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Drug Name Enzalutamide
Trade Name Xtandi
Synonyms MDV3100|ASP9785
Drug Descriptions

Xtandi (enzalutamide) is a second-generation small molecule inhibitor of androgen receptor, thereby resulting in decreased tumor growth (PMID: 24009414, PMID: 25945058). Xtandi (enzalutamide) is FDA-approved for use in patients with castration-resistant prostate cancer, metastatic hormone-sensitive prostate cancer, and non-metastatic castration-sensitive prostate cancer with biochemical recurrence at high risk for metastasis (FDA.gov).

DrugClasses Hormone - Anti-androgens 54
CAS Registry Number 915087-33-1
NCIT ID C71744

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Therapy Name Drugs Efficacy Evidence Clinical Trials
131I-MIP-1095 + Enzalutamide 131I-MIP-1095 Enzalutamide 0 1
177Lu-J591 + Enzalutamide 177Lu-J591 Enzalutamide 0 1
177Lu-J591 + Enzalutamide + Prednisolone 177Lu-J591 Enzalutamide Prednisolone 0 1
177Lu-J591 + Enzalutamide + Prednisone 177Lu-J591 Enzalutamide Prednisone 0 1
ABC294640 + Enzalutamide ABC294640 Enzalutamide 0 1
Abiraterone + Cabazitaxel + Carboplatin + Enzalutamide + Prednisone Abiraterone Cabazitaxel Carboplatin Enzalutamide Prednisone 0 1
Abiraterone + Cabazitaxel + Docetaxel + Enzalutamide Abiraterone Cabazitaxel Docetaxel Enzalutamide 0 0
Abiraterone + Denosumab + Enzalutamide + Prednisone Abiraterone Denosumab Enzalutamide Prednisone 0 1
Abiraterone + Docetaxel + Enzalutamide Abiraterone Docetaxel Enzalutamide 0 1
Abiraterone + Docetaxel + Enzalutamide + Prednisone Abiraterone Docetaxel Enzalutamide Prednisone 0 0
Abiraterone + Enzalutamide Abiraterone Enzalutamide 0 2
Abiraterone + Enzalutamide + Goserelin + Prednisone Abiraterone Enzalutamide Goserelin Prednisone 0 1
Abiraterone + Enzalutamide + lutetium Lu 177 vipivotide tetraxetan + Prednisone Abiraterone Enzalutamide Prednisone lutetium Lu 177 vipivotide tetraxetan 0 0
Abiraterone + Enzalutamide + Prednisolone Abiraterone Enzalutamide Prednisolone 0 1
Abiraterone + Enzalutamide + Prednisone Abiraterone Enzalutamide Prednisone 0 1
Abiraterone + Enzalutamide + Radium Ra 223 dichloride Abiraterone Enzalutamide Radium Ra 223 dichloride 0 1
Abiraterone + Enzalutamide + Tinengotinib Abiraterone Enzalutamide Tinengotinib 0 1
Alpelisib + AZD8186 + Enzalutamide AZD8186 Alpelisib Enzalutamide 1 0
Alpelisib + Enzalutamide Alpelisib Enzalutamide 0 1
AMG 160 + Enzalutamide AMG 160 Enzalutamide 0 1
Amoxicillin + Enzalutamide + Metronidazole Amoxicillin Enzalutamide Metronidazole 0 1
Anti-STEAP1 CAR-T cells + Enzalutamide Anti-STEAP1 CAR-T cells Enzalutamide 0 1
Atezolizumab + Enzalutamide Atezolizumab Enzalutamide 0 2
Avelumab + Enzalutamide Avelumab Enzalutamide 0 1
Avelumab + Enzalutamide + NKTR-214 Avelumab Enzalutamide NKTR-214 0 1
AZ505 + Enzalutamide AZ505 Enzalutamide 0 0
AZD5069 + Enzalutamide AZD5069 Enzalutamide 0 1
AZD5312 + Enzalutamide AZD5312 Enzalutamide 0 1
AZD8186 + Enzalutamide AZD8186 Enzalutamide 1 0
Cabazitaxel + Enzalutamide Cabazitaxel Enzalutamide 0 1
Camptothecin + Enzalutamide Camptothecin Enzalutamide 0 0
Capivasertib + Enzalutamide Capivasertib Enzalutamide 0 2
Carboplatin + Enzalutamide + Paclitaxel Carboplatin Enzalutamide Paclitaxel 0 1
Carotuximab + Enzalutamide Carotuximab Enzalutamide 0 1
CBP-1019 + Enzalutamide CBP-1019 Enzalutamide 0 1
CC-115 + Enzalutamide CC-115 Enzalutamide 4 1
CCS1477 + Enzalutamide CCS1477 Enzalutamide 0 1
Ciprofloxacin + Enzalutamide + Vancomycin Ciprofloxacin Enzalutamide Vancomycin 0 1
CORT125281 + Enzalutamide CORT125281 Enzalutamide 0 1
CPI-1205 + Enzalutamide CPI-1205 Enzalutamide 0 1
Crizotinib + Enzalutamide Crizotinib Enzalutamide 0 1
Dabrafenib + Enzalutamide + Trametinib Dabrafenib Enzalutamide Trametinib 1 0
Decitabine + Enzalutamide Decitabine Enzalutamide 0 1
Decitabine and Cedazuridine + Enzalutamide Decitabine and Cedazuridine Enzalutamide 0 1
Degarelix + Enzalutamide Degarelix Enzalutamide 0 2
Degarelix + Enzalutamide + Leuprolide + Talazoparib Degarelix Enzalutamide Leuprolide Talazoparib 0 0
Degarelix + Enzalutamide + Talazoparib Degarelix Enzalutamide Talazoparib 0 1
Denosumab + Enzalutamide Denosumab Enzalutamide 0 1
Docetaxel + Enzalutamide Docetaxel Enzalutamide 0 1
Docetaxel + Enzalutamide + lutetium Lu 177 vipivotide tetraxetan Docetaxel Enzalutamide lutetium Lu 177 vipivotide tetraxetan 0 1
Docetaxel + Enzalutamide + Prednisone Docetaxel Enzalutamide Prednisone 0 1
Dutasteride + Enzalutamide Dutasteride Enzalutamide 0 1
Entinostat + Enzalutamide Entinostat Enzalutamide 0 1
Enzalutamide Enzalutamide 2 114
Enzalutamide + Enzastaurin Enzalutamide Enzastaurin 0 0
Enzalutamide + EPI-7386 EPI-7386 Enzalutamide 0 2
Enzalutamide + Erdafitinib Enzalutamide Erdafitinib 0 1
Enzalutamide + Etrumadenant + Zimberelimab Enzalutamide Etrumadenant Zimberelimab 0 1
Enzalutamide + Everolimus Enzalutamide Everolimus 0 1
Enzalutamide + Exemestane Enzalutamide Exemestane 0 2
Enzalutamide + FOR46 Enzalutamide FOR46 0 1
Enzalutamide + Fulvestrant Enzalutamide Fulvestrant 0 2
Enzalutamide + G1T38 Enzalutamide G1T38 0 0
Enzalutamide + Goserelin Enzalutamide Goserelin 0 1
Enzalutamide + GSK2636771 Enzalutamide GSK2636771 1 0
Enzalutamide + Indomethacin Enzalutamide Indomethacin 0 1
Enzalutamide + Ipatasertib Enzalutamide Ipatasertib 0 0
Enzalutamide + ITRI-126 Enzalutamide ITRI-126 0 0
Enzalutamide + ITRI-90 Enzalutamide ITRI-90 0 0
Enzalutamide + Leuprolide Enzalutamide Leuprolide 0 2
Enzalutamide + Leuprolide + Talazoparib Enzalutamide Leuprolide Talazoparib 0 1
Enzalutamide + lutetium Lu 177 vipivotide tetraxetan Enzalutamide lutetium Lu 177 vipivotide tetraxetan 0 4
Enzalutamide + LY3023414 Enzalutamide LY3023414 0 0
Enzalutamide + MEDI3726 Enzalutamide MEDI3726 0 1
Enzalutamide + Metformin Enzalutamide Metformin 0 1
Enzalutamide + MI-503 Enzalutamide MI-503 0 0
Enzalutamide + Mifepristone Enzalutamide Mifepristone 0 1
Enzalutamide + Molibresib Enzalutamide Molibresib 0 1
Enzalutamide + NEO2734 Enzalutamide NEO2734 0 0
Enzalutamide + NHS-IL12 Enzalutamide NHS-IL12 0 1
Enzalutamide + Niclosamide Enzalutamide Niclosamide 0 1
Enzalutamide + Nivolumab Enzalutamide Nivolumab 0 1
Enzalutamide + NLG207 Enzalutamide NLG207 0 1
Enzalutamide + NUV-422 Enzalutamide NUV-422 0 1
Enzalutamide + NUV-868 Enzalutamide NUV-868 0 1
Enzalutamide + ORIC-101 Enzalutamide ORIC-101 0 1
Enzalutamide + Paclitaxel Enzalutamide Paclitaxel 0 2
Enzalutamide + Palbociclib Enzalutamide Palbociclib 0 0
Enzalutamide + Pembrolizumab Enzalutamide Pembrolizumab 0 6
Enzalutamide + Pembrolizumab + ZEN-3694 Enzalutamide Pembrolizumab ZEN-3694 0 1
Enzalutamide + Pertuzumab/trastuzumab/hyaluronidase-zzxf Enzalutamide Pertuzumab/trastuzumab/hyaluronidase-zzxf 0 1
Enzalutamide + PF-06821497 Enzalutamide PF-06821497 0 2
Enzalutamide + PF-06952229 Enzalutamide PF-06952229 0 1
Enzalutamide + PMD-026 Enzalutamide PMD-026 0 0
Enzalutamide + Prednisolone Enzalutamide Prednisolone 0 1
Enzalutamide + Prednisone Enzalutamide Prednisone 0 1
Enzalutamide + PROSTVAC-F-TRICOM Enzalutamide PROSTVAC-F-TRICOM 0 0
Enzalutamide + PROSTVAC-F-TRICOM + PROSTVAC-V-TRICOM Enzalutamide PROSTVAC-F-TRICOM PROSTVAC-V-TRICOM 0 1
Enzalutamide + PROSTVAC-V-TRICOM Enzalutamide PROSTVAC-V-TRICOM 0 0
Enzalutamide + Radium Ra 223 dichloride Enzalutamide Radium Ra 223 dichloride 0 3
Enzalutamide + Relacorilant Enzalutamide Relacorilant 0 2
Enzalutamide + Relugolix Enzalutamide Relugolix 0 3
Enzalutamide + Rucaparib Enzalutamide Rucaparib 0 2
Enzalutamide + Ruxolitinib Enzalutamide Ruxolitinib 0 1
Enzalutamide + Saracatinib Enzalutamide Saracatinib 0 0
Enzalutamide + Saruparib Enzalutamide Saruparib 0 2
Enzalutamide + Sipuleucel-T Enzalutamide Sipuleucel-T 0 1
Enzalutamide + SX-682 Enzalutamide SX-682 0 1
Enzalutamide + Talazoparib Enzalutamide Talazoparib 10 3
Enzalutamide + Tanespimycin Enzalutamide Tanespimycin 0 0
Enzalutamide + Taselisib Enzalutamide Taselisib 0 1
Enzalutamide + Tazemetostat Enzalutamide Tazemetostat 0 1
Enzalutamide + Testosterone Enzalutamide Testosterone 0 2
Enzalutamide + Tinengotinib Enzalutamide Tinengotinib 0 0
Enzalutamide + Tivozanib Enzalutamide Tivozanib 0 1
Enzalutamide + Trastuzumab Enzalutamide Trastuzumab 0 1
Enzalutamide + Triptorelin Enzalutamide Triptorelin 0 2
Enzalutamide + Triptorelin + Zoledronic acid Enzalutamide Triptorelin Zoledronic acid 0 1
Enzalutamide + TT-702 Enzalutamide TT-702 0 0
Enzalutamide + TVB-2640 Enzalutamide TVB-2640 0 1
Enzalutamide + Venetoclax Enzalutamide Venetoclax 0 1
Enzalutamide + XmAb20717 Enzalutamide XmAb20717 0 1
Enzalutamide + ZEN-3694 Enzalutamide ZEN-3694 0 3
Enzalutamide + Zenocutuzumab Enzalutamide Zenocutuzumab 0 1
Enzalutamide + Zoledronic acid Enzalutamide Zoledronic acid 0 0


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