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Drug Name | Lovastatin |
Trade Name | |
Synonyms | lovastatin sodium|mevacor|mevinolin|monacolin K |
Drug Descriptions |
Lovastatin is a metabolite inhibitor of HMG-CoA reductase, which induces mitochondrial dysfunction leading to increased production of reactive oxygen species (ROS) and mtDNA damage, potentially resulting in tumor cell apoptosis (PMID: 38929118). |
DrugClasses | |
CAS Registry Number | 75330-75-5 |
NCIT ID | C620 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Lovastatin | Lovastatin | 0 | 0 |
Lovastatin + Pembrolizumab | Lovastatin Pembrolizumab | 0 | 1 |