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Drug Name ONC212
Trade Name
Synonyms ONC 212|ONC-212
Drug Descriptions

ONC212 is a trifluoromethylbenzyl imipridone that activates cellular stress response pathways, inhibits tumor metabolic pathways, and decreases FOXO3, AKT, ERK and mTOR signaling and levels of Myc, potentially leading to increased tumor cell apoptosis, cell cycle arrest, and tumor growth inhibition (PMID: 30037819, PMID: 28489985).

DrugClasses
CAS Registry Number 1807861-48-8
NCIT ID NA

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Therapy Name Drugs Efficacy Evidence Clinical Trials
MRTX-1133 + ONC212 MRTX-1133 ONC212 0 0
ONC212 ONC212 0 0


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