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Drug Name | ONC212 |
Trade Name | |
Synonyms | ONC 212|ONC-212 |
Drug Descriptions |
ONC212 is a trifluoromethylbenzyl imipridone that activates cellular stress response pathways, inhibits tumor metabolic pathways, and decreases FOXO3, AKT, ERK and mTOR signaling and levels of Myc, potentially leading to increased tumor cell apoptosis, cell cycle arrest, and tumor growth inhibition (PMID: 30037819, PMID: 28489985). |
DrugClasses | |
CAS Registry Number | 1807861-48-8 |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
MRTX-1133 + ONC212 | MRTX-1133 ONC212 | 0 | 0 |
ONC212 | ONC212 | 0 | 0 |