A2B395
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| Drug Name | A2B395 |
| Trade Name | |
| Synonyms | A-2B395|A 2B395 |
| Drug Descriptions |
A2B395 comprises allogeneic T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting EGFR, and containing an HLA-A*02-targeted LIR-1-based inhibitory receptor, and shRNA targeting beta2 microglobulin (B2M), which potentially induce killing of tumor cells expressing EGFR with loss of heterozygosity for HLA-A*02 (J Clin Oncol 2025 43: 16_suppl, TPS2677, NCI Drug Dictionary). |
| DrugClasses | EGFR Immune Cell Therapy 5 |
| CAS Registry Number | NA |
| NCIT ID | C214776 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| A2B395 | A2B395 | 0 | 1 |
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