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Therapy Name A2B395
Synonyms
Therapy Description

A2B395 comprises allogeneic T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting EGFR, and containing an HLA-A*02-targeted LIR-1-based inhibitory receptor, and shRNA targeting beta2 microglobulin (B2M), which potentially induce killing of tumor cells expressing EGFR with loss of heterozygosity for HLA-A*02 (J Clin Oncol 2025 43: 16_suppl, TPS2677, NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
A2B395 A-2B395|A 2B395 EGFR Immune Cell Therapy 5 A2B395 comprises allogeneic T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting EGFR, and containing an HLA-A*02-targeted LIR-1-based inhibitory receptor, and shRNA targeting beta2 microglobulin (B2M), which potentially induce killing of tumor cells expressing EGFR with loss of heterozygosity for HLA-A*02 (J Clin Oncol 2025 43: 16_suppl, TPS2677, NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06682793 Phase Ib/II A2B395 A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression (DENALI-1) Recruiting USA 0


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