Ad5NULL-A20.FCU1
Drug Detail
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| Drug Name | Ad5NULL-A20.FCU1 |
| Trade Name | |
| Synonyms | |
| Drug Descriptions |
Ad5NULL-A20.FCU1 is a replication-deficient adenovirus engineered to contain a peptide that binds ITGB6 (integrin alphaVbeta6) and to express FCU1, a bifunctional chimeric protein of CD and UPRTase that converts the prodrug 5-fluorocytosine (5-FC) to 5-fluorouracil (5-FU) and 5-fluorouridine monophosphate (5-FUMP), which potentially induces toxicity against tumor cells expressing ITGB6 (integrin alphaVbeta6) and inhibits tumor growth (PMID: 39369056). |
| DrugClasses | |
| CAS Registry Number | NA |
| NCIT ID | NA |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Ad5NULL-A20.FCU1 | Ad5NULL-A20.FCU1 | 0 | 0 |
| Ad5NULL-A20.FCU1 + Flucytosine | Ad5NULL-A20.FCU1 Flucytosine | 0 | 0 |
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