Therapy Detail
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| Therapy Name | Ad5NULL-A20.FCU1 + Flucytosine |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Ad5NULL-A20.FCU1 | Ad5NULL-A20.FCU1 is a replication-deficient adenovirus engineered to contain a peptide that binds ITGB6 (integrin alphaVbeta6) and to express FCU1, a bifunctional chimeric protein of CD and UPRTase that converts the prodrug 5-fluorocytosine (5-FC) to 5-fluorouracil (5-FU) and 5-fluorouridine monophosphate (5-FUMP), which potentially induces toxicity against tumor cells expressing ITGB6 (integrin alphaVbeta6) and inhibits tumor growth (PMID: 39369056). | |||
| Flucytosine | Ancobon | 5-FC |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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