Allogeneic CD19-CD28-CD3-zeta CAR-T cells
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| Drug Name | Allogeneic CD19-CD28-CD3-zeta CAR-T cells |
| Trade Name | |
| Synonyms | Allogeneic 19-28z CAR T-cells|Allogeneic CD19-28z CAR T Cells |
| Drug Descriptions |
Allogeneic CD19-CD28-CD3-zeta CAR-T cells are allogeneic T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting CD19 linked to the CD28 co-stimulatory receptor and CD3zeta, which potentially induce toxicity in CD19-expressing tumor cells (NCI Drug Dictionary). |
| DrugClasses | CD19 Immune Cell Therapy 72 |
| CAS Registry Number | NA |
| NCIT ID | C178433 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Allogeneic CD19-CD28-CD3-zeta CAR-T cells | Allogeneic CD19-CD28-CD3-zeta CAR-T cells | 0 | 0 |
| Allogeneic CD19-CD28-CD3-zeta CAR-T cells + Mycophenolate mofetil + Sirolimus | Allogeneic CD19-CD28-CD3-zeta CAR-T cells Mycophenolate mofetil Sirolimus | 0 | 1 |
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