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| Drug Name | Sirolimus |
| Trade Name | Rapamune |
| Synonyms | Rapamycin |
| Drug Descriptions |
Rapamune (sirolimus) binds to the FKBP-12 to generate an immunosuppressive complex that binds and allosterically inhibits mTOR (PMID: 25261369). Rapamune (sirolimus) is FDA approved for the prevention of renal transplant rejection and for patients with lymphangioleiomyomatosis (FDA.gov). |
| DrugClasses | mTORC1 Inhibitor 9 |
| CAS Registry Number | 53123-88-9 |
| NCIT ID | C1212 |
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