AZD1480
Drug Detail
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| Drug Name | AZD1480 |
| Trade Name | |
| Synonyms | AZD-1480 |
| Drug Descriptions |
AZD1480 is an ATP-competitive inhibitor of JAK1 and JAK2, which reduces STAT3 activation, potentially resulting in decreased tumor growth (PMID: 22027691, PMID: 24158701) and has been also shown to inhibit ALK, LTK, FGFR1-3, RET and TRKA-C kinases (PMID: 29312610). |
| DrugClasses | JAK1 Inhibitor - ATP competitive 5 JAK2 Inhibitor - ATP competitive 15 |
| CAS Registry Number | 935666-88-9 |
| NCIT ID | C91394 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| AZD1480 | AZD1480 | 12 | 0 |
| AZD1480 + CUDC-907 | AZD1480 CUDC-907 | 1 | 0 |
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