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Drug Name | AZD1480 |
Trade Name | |
Synonyms | AZD-1480 |
Drug Descriptions |
AZD1480 is an ATP-competitive inhibitor of JAK1 and JAK2, which reduces STAT3 activation, potentially resulting in decreased tumor growth (PMID: 22027691, PMID: 24158701) and has been also shown to inhibit ALK, LTK, FGFR1-3, RET and TRKA-C kinases (PMID: 29312610). |
DrugClasses | JAK1 Inhibitor - ATP competitive 5 JAK2 Inhibitor - ATP competitive 15 |
CAS Registry Number | 935666-88-9 |
NCIT ID | C91394 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
AZD1480 | AZD1480 | 12 | 0 |
AZD1480 + CUDC-907 | AZD1480 CUDC-907 | 1 | 0 |