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Drug Name | CUDC-907 |
Trade Name | |
Synonyms | Fimepinostat |
Drug Descriptions |
CUDC-907 (fimepinostat) is a dual PI3K and HDAC inhibitor, which prevents activation of the PI3K-AKT-mTOR signal transduction pathway, inhibits tumor cell growth, and promotes apoptosis in cancer cells (PMID: 22693356, PMID: 32459381). |
DrugClasses | HDAC Inhibitor 45 PI3K Inhibitor (Pan) 42 |
CAS Registry Number | 1339928-25-4 |
NCIT ID | C104008 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
AZD1480 + CUDC-907 | AZD1480 CUDC-907 | 1 | 0 |
Bendamustine + CUDC-907 + Rituximab | Bendamustine CUDC-907 Rituximab | 0 | 1 |
CUDC-907 | CUDC-907 | 5 | 6 |
CUDC-907 + Gilteritinib | CUDC-907 Gilteritinib | 1 | 0 |
CUDC-907 + Rituximab | CUDC-907 Rituximab | 0 | 1 |
CUDC-907 + Venetoclax | CUDC-907 Venetoclax | 0 | 1 |