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Drug Name | Seribantumab |
Trade Name | |
Synonyms | MM-121|SAR256212 |
Drug Descriptions |
Seribantumab (SAR256212) is a human monoclonal antibody that binds ERBB3 (HER3) and prevents ligand binding and heterodimerization with other ERBB family members, resulting in decreased activation of downstream signaling and potentially leading to reduced tumor growth (PMID: 26310543, PMID: 30975923). |
DrugClasses | HER3 (ERBB3) Antibody 23 |
CAS Registry Number | 1334296-12-6 |
NCIT ID | C78859 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Erlotinib + Seribantumab | Erlotinib Seribantumab | 0 | 0 |
Exemestane + Seribantumab | Exemestane Seribantumab | 0 | 0 |
Fulvestrant + Seribantumab | Fulvestrant Seribantumab | 0 | 1 |
Letrozole + Seribantumab | Letrozole Seribantumab | 0 | 0 |
Seribantumab | Seribantumab | 0 | 3 |
Seribantumab + XL147 | Seribantumab XL147 | 0 | 0 |