XL147
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| Drug Name | XL147 |
| Trade Name | |
| Synonyms | SAR245408|Pilaralisib|XL-147 |
| Drug Descriptions |
Pilaralisib (XL147) is an inhibitor of all class I PI3Ks, thereby blocking activation of the PI3K signaling pathway and potentially resulting in antitumor activity including inhibition of cell proliferation, cell invasion, and tumor growth (PMID: 25637314, PMID: 29593099). |
| DrugClasses | PI3K Inhibitor (Pan) 42 |
| CAS Registry Number | 934526-89-3 |
| NCIT ID | C71705 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Carboplatin + Paclitaxel + XL147 | Carboplatin Paclitaxel XL147 | 0 | 0 |
| Carboplatin + XL147 | Carboplatin XL147 | 0 | 0 |
| Paclitaxel + XL147 | Paclitaxel XL147 | 1 | 0 |
| Seribantumab + XL147 | Seribantumab XL147 | 0 | 0 |
| Trastuzumab + XL147 | Trastuzumab XL147 | 0 | 0 |
| Voxtalisib + XL147 | Voxtalisib XL147 | 0 | 0 |
| XL147 | XL147 | 9 | 1 |
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