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Drug Name | Momelotinib |
Trade Name | |
Synonyms | CYT387|CYT-387|GS-0387 |
Drug Descriptions |
Momelotinib (CYT387) is an ATP-competitive and selective inhibitor of JAK1 and JAK2, which inhibits cell proliferation and promotes apoptosis (PMID: 19295546, PMID: 31733040, PMID: 32394008). |
DrugClasses | JAK1 Inhibitor - ATP competitive 5 JAK2 Inhibitor - ATP competitive 15 |
CAS Registry Number | 1056634-68-4 |
NCIT ID | C88311 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Erlotinib + Momelotinib | Erlotinib Momelotinib | 0 | 1 |
Gilteritinib + Momelotinib | Gilteritinib Momelotinib | 0 | 1 |
Momelotinib | Momelotinib | 17 | 6 |
Momelotinib + Trametinib | Momelotinib Trametinib | 0 | 1 |