Momelotinib
Drug Detail
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| Drug Name | Momelotinib |
| Trade Name | |
| Synonyms | CYT387|CYT-387|GS-0387 |
| Drug Descriptions |
Momelotinib (CYT387) is an ATP-competitive and selective inhibitor of JAK1 and JAK2, which inhibits cell proliferation and promotes apoptosis (PMID: 19295546, PMID: 31733040, PMID: 32394008). |
| DrugClasses | JAK1 Inhibitor - ATP competitive 5 JAK2 Inhibitor - ATP competitive 15 |
| CAS Registry Number | 1056634-68-4 |
| NCIT ID | C88311 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Erlotinib + Momelotinib | Erlotinib Momelotinib | 0 | 1 |
| Gilteritinib + Momelotinib | Gilteritinib Momelotinib | 0 | 1 |
| Luspatercept + Momelotinib | Luspatercept Momelotinib | 0 | 1 |
| Momelotinib | Momelotinib | 19 | 7 |
| Momelotinib + Trametinib | Momelotinib Trametinib | 0 | 1 |
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