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| Drug Name | Nirogacestat |
| Trade Name | Ogsiveo |
| Synonyms | PF-03084014|PF 03084014|PF03084014 |
| Drug Descriptions |
Ogsiveo (nirogacestat) is a small molecule that selectively binds to Gamma-secretase and inhibits its proteolytic activity on downstream targets including NOTCH receptor proteins, thus blocking NOTCH pathway activation in cancer (PMID: 28887726, PMID: 31211955). Ogsiveo (nirogacestat) is FDA-approved for use in patients with progressing desmoid tumors (FDA.gov). |
| DrugClasses | Gamma secretase inhibitor 13 |
| CAS Registry Number | 1290543-63-3 |
| NCIT ID | C82383 |
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