RAF265
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| Drug Name | RAF265 |
| Trade Name | |
| Synonyms | CHIR-265|NVP-RAF265 |
| Drug Descriptions |
RAF265 inhibits the activities of several intracellular kinases, including BRAF(V600E), BRAF(wild type), c-RAF (RAF1), VEGF receptor 2 (VEGFR2/KDR), platelet-derived growth factor receptor (PDGFR), colony-stimulating factor (CSF)1R, RET and c-KIT, SRC, STE20, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death (PMID: 22351689, PMID: 28719152). |
| DrugClasses | BRAF Inhibitor 26 CRAF Inhibitor 12 VEGFR2 Inhibitor 37 |
| CAS Registry Number | 927880-90-8 |
| NCIT ID | C61311 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Cisplatin + RAF265 | Cisplatin RAF265 | 0 | 0 |
| RAF265 | RAF265 | 12 | 0 |
| RAF265 + Selumetinib | RAF265 Selumetinib | 0 | 0 |
| RAF265 + Trametinib | RAF265 Trametinib | 3 | 0 |
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