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Drug Name | SYM004 |
Trade Name | |
Synonyms | Symphogen |
Drug Descriptions |
Symphogen (Sym004) is comprised of two antibodies (Futuximab and Modotuximab) that bind EGFR and prevent ligand binding, which may prevent downstream signaling and result in decreased tumor cell proliferation (PMID: 31959764, PMID: 31679083). |
DrugClasses | EGFR Antibody 61 |
CAS Registry Number | NA |
NCIT ID | C91381 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Fluorouracil + Irinotecan + Leucovorin + SYM004 | Fluorouracil Irinotecan Leucovorin SYM004 | 0 | 1 |
Nivolumab + SYM004 | Nivolumab SYM004 | 0 | 1 |
Radiotherapy + SYM004 | Radiotherapy SYM004 | 0 | 0 |
SYM004 | SYM004 | 2 | 4 |