SYM004
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| Drug Name | SYM004 |
| Trade Name | |
| Synonyms | Symphogen |
| Drug Descriptions |
Symphogen (Sym004) is comprised of two antibodies (Futuximab and Modotuximab) that bind EGFR and prevent ligand binding, which may prevent downstream signaling and result in decreased tumor cell proliferation (PMID: 31959764, PMID: 31679083). |
| DrugClasses | EGFR Antibody 72 |
| CAS Registry Number | NA |
| NCIT ID | C91381 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Fluorouracil + Irinotecan + Leucovorin + SYM004 | Fluorouracil Irinotecan Leucovorin SYM004 | 0 | 1 |
| Nivolumab + SYM004 | Nivolumab SYM004 | 0 | 1 |
| Radiotherapy + SYM004 | Radiotherapy SYM004 | 0 | 0 |
| SYM004 | SYM004 | 2 | 4 |
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