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| Drug Name | 7-hydroxystaurosporine |
| Trade Name | |
| Synonyms | UCN-01|KRX-0601|NSC-638850 |
| Drug Descriptions |
7-hydroxystaurosporine (UCN-01) is a derivative of staurosporine that inhibits CHK1 and PKC, with higher potency toward PKC-alpha, PKC-beta, and PKC-gamma, and also modulates CDK activity through upregulation of CDK inhibitors, potentially resulting in inhibition of tumor growth (PMID: 8022414, PMID: 15831461, PMID: 15150122, PMID: 31942030). |
| DrugClasses | CDK Inhibitor (Pan) 3 CHK1 Inhibitor 18 PKC alpha Inhibitor 6 PKC beta Inhibitor 6 PKC Inhibitor (Pan) 11 |
| CAS Registry Number | 112953-11-4 |
| NCIT ID | C1271 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| 7-hydroxystaurosporine | 7-hydroxystaurosporine | 0 | 0 |
| 7-hydroxystaurosporine + Sirolimus | 7-hydroxystaurosporine Sirolimus | 0 | 0 |
CKB BOOST