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Drug Name | SNX-5422 |
Trade Name | |
Synonyms | PF-04929113|PF 04929113|SNX 5422 |
Drug Descriptions |
SNX-5422 (PF-04929113) is the prodrug of the potent Hsp90 inhibitor SNX-2112, which has been shown to decrease activation Her-2, Akt, and ERK, inhibit tumor cell proliferation, and induce tumor cell apoptosis (PMID: 21349995, PMID: 18948577, PMID: 32468060). |
DrugClasses | HSP90 Inhibitor 35 |
CAS Registry Number | 908115-27-5 |
NCIT ID | C141504 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Carboplatin + Paclitaxel + SNX-5422 | Carboplatin Paclitaxel SNX-5422 | 0 | 0 |
Ibrutinib + SNX-5422 | Ibrutinib SNX-5422 | 0 | 2 |
SNX-5422 | SNX-5422 | 0 | 5 |