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| Drug Name | Ibrutinib |
| Trade Name | Imbruvica |
| Synonyms | PCI-32765 |
| Drug Descriptions |
Imbruvica (ibrutinib) is a selective, irreversible inhibitor of Bruton's tyrosine kinase (BTK), which promotes apoptosis and inhibits B-cell mediated signaling pathways, and has additional activity against ERBB2 (HER2) and EGFR (PMID: 20615965, PMID: 21422473, PMID: 27678331). Imbruvica (Ibrutinib) is FDA approved for use in patients with mantle cell lymphoma, CLL/SLL and CLL/SLL with del 17p, Waldenstroem’s macroglobulinemia, marginal zone lymphoma, and in combination with Rituxan (rituximab) for untreated CLL/SLL (FDA.gov). |
| DrugClasses | BTK inhibitor 37 EGFR Inhibitor (Pan) 62 HER2 Inhibitor 42 |
| CAS Registry Number | 936563-96-1 |
| NCIT ID | C81934 |
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