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Drug Name Ad5CMV-p53 gene
Trade Name
Synonyms Advexin|INGN-201|RPR/INGN-201|Adeno-p53|Ad-p53
Drug Descriptions

Advexin (Ad5CMV-p53) is a replication-defective adenoviral-CMV vector that encodes a wild-type Tp53 gene, which induces tumor cells to produce wild-type Tp53 to block cell cycle progression (PMID: 19169960).

DrugClasses p53 Gene Therapy 4
CAS Registry Number 600735-73-7
NCIT ID C2471

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Ad5CMV-p53 gene Ad5CMV-p53 gene 1 0
Ad5CMV-p53 gene + Capecitabine Ad5CMV-p53 gene Capecitabine 0 1
Ad5CMV-p53 gene + Nivolumab Ad5CMV-p53 gene Nivolumab 0 2
Ad5CMV-p53 gene + Pembrolizumab Ad5CMV-p53 gene Pembrolizumab 0 1
Ad5CMV-p53 gene + unspecified PD-1 antibody Ad5CMV-p53 gene unspecified PD-1 antibody 0 0


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