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| Drug Name | Ad5CMV-p53 gene |
| Trade Name | |
| Synonyms | Advexin|INGN-201|RPR/INGN-201|Adeno-p53|Ad-p53 |
| Drug Descriptions |
Advexin (Ad5CMV-p53) is a replication-defective adenoviral-CMV vector that encodes a wild-type Tp53 gene, which induces tumor cells to produce wild-type Tp53 to block cell cycle progression (PMID: 19169960). |
| DrugClasses | p53 Gene Therapy 4 |
| CAS Registry Number | 600735-73-7 |
| NCIT ID | C2471 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Ad5CMV-p53 gene | Ad5CMV-p53 gene | 1 | 0 |
| Ad5CMV-p53 gene + Capecitabine | Ad5CMV-p53 gene Capecitabine | 0 | 1 |
| Ad5CMV-p53 gene + Nivolumab | Ad5CMV-p53 gene Nivolumab | 0 | 2 |
| Ad5CMV-p53 gene + Pembrolizumab | Ad5CMV-p53 gene Pembrolizumab | 0 | 1 |
| Ad5CMV-p53 gene + unspecified PD-1 antibody | Ad5CMV-p53 gene unspecified PD-1 antibody | 0 | 0 |
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