MM-141
Drug Detail
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| Drug Name | MM-141 |
| Trade Name | |
| Synonyms | Istiratumab |
| Drug Descriptions |
Istiratumab (MM-141) is a monoclonal antibody, which binds to human epidermal growth factor receptor B3 (ERBB3) and the human insulin-like growth factor-1 receptor (IGF-1R), blocking ligand binding and preventing activation of PI3K/AKT signaling (PMID: 24282274, PMID: 31912800). |
| DrugClasses | HER3 (ERBB3) Antibody 28 IGF1R Antibody 8 |
| CAS Registry Number | 1509928-04-4 |
| NCIT ID | C103863 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Everolimus + MM-141 | Everolimus MM-141 | 0 | 1 |
| Gemcitabine + MM-141 + Nab-paclitaxel | Gemcitabine MM-141 Nab-paclitaxel | 0 | 1 |
| MM-141 | MM-141 | 0 | 2 |
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