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| Drug Name | Everolimus |
| Trade Name | Afinitor |
| Synonyms | RAD001|Zortress |
| Drug Descriptions |
Afinitor (everolimus) binds to FKBP-12 and allosterically inhibits mTOR, leading to decreased mTORC1 signaling and potentially resulting in decreased tumor cell growth (PMID: 17766661, PMID: 28400999). Afinitor (everolimus) is FDA approved for use in neuroendocrine tumors of pancreatic, lung or gastrointestinal tract origin, advanced renal cell carcinoma, in adult and pediatric patients aged 1 year and older with tuberous sclerosis complex who have subependymal giant cell astrocytoma, and in combination with Aromasin (exemestane) in hormone receptor-positive, HER2-negative breast cancer (FDA.gov). |
| DrugClasses | mTORC1 Inhibitor 9 |
| CAS Registry Number | 159351-69-6 |
| NCIT ID | C48387 |
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