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Drug Name Fosbretabulin
Trade Name
Synonyms
Drug Descriptions

Fosbretabulin is metabolized to combretastatin A4, which binds to tubulin dimers, preventing microtubule polymerization. This causes mitotic arrest and apoptosis in endothelial cells, leading to collapse of tumor blood cells, disrupting blood flow to the tumor and possibly causing tumor necrosis (PMID: 31932108).

DrugClasses
CAS Registry Number 222030-63-9
NCIT ID C82378

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Bevacizumab + Fosbretabulin Bevacizumab Fosbretabulin 0 1
Everolimus + Fosbretabulin Everolimus Fosbretabulin 0 1
Fosbretabulin Fosbretabulin 0 1


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