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Drug Name | HMN-214 |
Trade Name | |
Synonyms | |
Drug Descriptions |
HMN-214 is a prodrug of the active agent HMN-176, which interferes with the location of PLK1, leading to cell cycle arrest, destruction of the spindle polar bodies, and DNA fragmentation (PMID: 19474163, PMID: 16951237). |
DrugClasses | PLK1 Inhibitor 18 |
CAS Registry Number | 173529-46-9 |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
HMN-214 | HMN-214 | 0 | 0 |
HMN-214 + Palbociclib | HMN-214 Palbociclib | 1 | 0 |