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Drug Name | PF-00477736 |
Trade Name | |
Synonyms | PF-477736 |
Drug Descriptions |
PF-00477736 is an ATP-competitive inhibitor of Chk1, which potentially increases sensitivity to chemotherapeutic agents, resulting in decreased tumor growth (PMID: 18723486). |
DrugClasses | CHK1 Inhibitor 18 |
CAS Registry Number | 952021-60-2 |
NCIT ID | C68820 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Adavosertib + PF-00477736 | Adavosertib PF-00477736 | 1 | 0 |
Gemcitabine + PF-00477736 | Gemcitabine PF-00477736 | 0 | 0 |
PF-00477736 | PF-00477736 | 1 | 0 |
PF-00477736 + PF3644022 | PF-00477736 PF3644022 | 6 | 0 |