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Drug Name Adavosertib
Trade Name
Synonyms MK-1775|AZD1775|AZ1775|MK1775
Drug Descriptions

Adavosertib (MK-1775) is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity (PMID: 22084170, PMID: 32611648).

DrugClasses WEE1 Inhibitor 8
CAS Registry Number 955365-80-7
NCIT ID C91725

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Adavosertib Adavosertib 13 24
Adavosertib + Alisertib Adavosertib Alisertib 0 0
Adavosertib + Avapritinib Adavosertib Avapritinib 2 0
Adavosertib + AZD8055 AZD8055 Adavosertib 0 0
Adavosertib + Belinostat Adavosertib Belinostat 0 1
Adavosertib + Berzosertib Adavosertib Berzosertib 0 0
Adavosertib + Carboplatin Adavosertib Carboplatin 3 3
Adavosertib + Carboplatin + Paclitaxel Adavosertib Carboplatin Paclitaxel 1 0
Adavosertib + Cisplatin Adavosertib Cisplatin 0 3
Adavosertib + Cisplatin + Docetaxel Adavosertib Cisplatin Docetaxel 0 0
Adavosertib + Doxorubicin Adavosertib Doxorubicin 0 0
Adavosertib + Durvalumab Adavosertib Durvalumab 0 2
Adavosertib + Everolimus Adavosertib Everolimus 0 0
Adavosertib + Gemcitabine Adavosertib Gemcitabine 2 4
Adavosertib + Gemcitabine + Radiotherapy Adavosertib Gemcitabine Radiotherapy 0 0
Adavosertib + Irinotecan Adavosertib Irinotecan 0 2
Adavosertib + Itraconazole Adavosertib Itraconazole 0 1
Adavosertib + Olaparib Adavosertib Olaparib 0 4
Adavosertib + Omeprazole Adavosertib Omeprazole 0 1
Adavosertib + Paclitaxel Adavosertib Paclitaxel 0 1
Adavosertib + Pegylated liposomal doxorubicin Adavosertib Pegylated liposomal doxorubicin 0 1
Adavosertib + PF-00477736 Adavosertib PF-00477736 1 0
Adavosertib + Radiotherapy Adavosertib Radiotherapy 5 0
Adavosertib + Rifampin Adavosertib Rifampin 0 1
Adavosertib + Sotorasib Adavosertib Sotorasib 0 0
Adavosertib + STP-B Adavosertib STP-B 0 0
Adavosertib + Temozolomide Adavosertib Temozolomide 0 1
Adavosertib + Trastuzumab deruxtecan Adavosertib Trastuzumab deruxtecan 0 0


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