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Drug Name | ZM336372 |
Trade Name | |
Synonyms | ZM 336372|ZM-336372 |
Drug Descriptions |
ZM336372 is a small molecule RAF1 inhibitor that paradoxically causes RAF1 activation through a putative feedback mechanism, resulting in decreased proliferation and cell cycle inhibition in carcinoid tumor cells (PMID: 20031160, PMID: 15956248). |
DrugClasses | CRAF Inhibitor 12 |
CAS Registry Number | 208260-29-1 |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Vemurafenib + ZM336372 | Vemurafenib ZM336372 | 1 | 0 |
ZM336372 | ZM336372 | 1 | 0 |