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| Drug Name | Vemurafenib |
| Trade Name | Zelboraf |
| Synonyms | RO5185426|PLX4032 |
| Drug Descriptions |
Zelboraf (vemurafenib) inhibits BRAF V600E, wild-type BRAF, ARAF, and CRAF (PMID: 20179705), which may result in an inhibition of the MAPK signaling pathway resulting in a reduction of tumor cell proliferation (PMID: 20823850). Zelboraf (vemurafenib) is FDA approved for BRAF V600E-mutant melanoma and for BRAF V600-positive Erdheim-Chester disease (FDA.gov). |
| DrugClasses | RAF Inhibitor (Pan) 28 |
| CAS Registry Number | 918504-65-1 |
| NCIT ID | C64768 |
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