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Drug Name | Edelfosine |
Trade Name | |
Synonyms | ET-18-OCH3 |
Drug Descriptions |
Edelfosine (ET-18-OCH3) is an ether lipid that modulates cell membrane properties, inhibits PKC, and inhibits the PI3K-AKT/PKB pathway, activating the pro-apoptotic stress-activated protein kinase SAPK/JNK pathways, thereby inducing apoptosis selectively in tumor cells (PMID: 9257915, PMID: 32674353). |
DrugClasses | |
CAS Registry Number | 77286-66-9 |
NCIT ID | C956 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Clofarabine + Edelfosine + Gemcitabine | Clofarabine Edelfosine Gemcitabine | 0 | 0 |
Edelfosine | Edelfosine | 0 | 0 |