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Therapy Name | Edelfosine |
Synonyms | |
Therapy Description |
Edelfosine (ET-18-OCH3) is an ether lipid that modulates cell membrane properties, inhibits PKC, and inhibits the PI3K-AKT/PKB pathway, activating the pro-apoptotic stress-activated protein kinase SAPK/JNK pathways, thereby inducing apoptosis selectively in tumor cells (PMID: 9257915, PMID: 32674353). |