VS-4718
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| Drug Name | VS-4718 |
| Trade Name | |
| Synonyms | |
| Drug Descriptions |
VS-4718 is a focal adhesion kinase (FAK) inhibitor, which prevents FAK autophosphorylation and activation of downstream YAP1 and Hippo pathway signaling, potentially resulting in decreased tumor cell proliferation, migration, and survival (PMID: 30773340). |
| DrugClasses | FAK inhibitor 16 |
| CAS Registry Number | 1061353-68-1 |
| NCIT ID | C107238 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Cobimetinib + VS-4718 | Cobimetinib VS-4718 | 0 | 0 |
| Gemcitabine + Nab-paclitaxel + VS-4718 | Gemcitabine Nab-paclitaxel VS-4718 | 0 | 1 |
| RO5126766 + VS-4718 | RO5126766 VS-4718 | 0 | 0 |
| Selumetinib + VS-4718 | Selumetinib VS-4718 | 0 | 0 |
| Trametinib + VS-4718 | Trametinib VS-4718 | 0 | 0 |
| VS-4718 | VS-4718 | 0 | 1 |
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