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Drug Name Cobimetinib
Trade Name Cotellic
Synonyms GDC-0973
Drug Descriptions

Cotellic (cobimetinib) is an allosteric inhibitor of MEK1/2, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation (PMID: 22084396, PMID: 27956260). Cotellic (cobimetinib) is FDA approved for use in combination with Zelboraf (vemurafenib) in melanoma patients harboring BRAF V600E or V600K (FDA.gov).

DrugClasses MEK inhibitor (Pan) 26 MEK1 Inhibitor 26 MEK2 Inhibitor 24
CAS Registry Number 934660-93-2
NCIT ID C68923

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Therapy Name Drugs Efficacy Evidence Clinical Trials
A-1210477 + Cobimetinib A-1210477 Cobimetinib 0 0
A-1210477 + Cobimetinib + Vemurafenib A-1210477 Cobimetinib Vemurafenib 0 0
ABM-1310 + Cobimetinib ABM-1310 Cobimetinib 1 1
Alectinib + Cobimetinib Alectinib Cobimetinib 0 1
APG-1252 + Cobimetinib APG-1252 Cobimetinib 0 1
Atezolizumab + Belvarafenib + Cobimetinib Atezolizumab Belvarafenib Cobimetinib 0 0
Atezolizumab + Bevacizumab + Cobimetinib Atezolizumab Bevacizumab Cobimetinib 0 3
Atezolizumab + Cobimetinib Atezolizumab Cobimetinib 0 18
Atezolizumab + Cobimetinib + Eribulin Atezolizumab Cobimetinib Eribulin 0 1
Atezolizumab + Cobimetinib + Fluorouracil + Leucovorin + Oxaliplatin Atezolizumab Cobimetinib Fluorouracil Leucovorin Oxaliplatin 0 1
Atezolizumab + Cobimetinib + Hydroxychloroquine Atezolizumab Cobimetinib Hydroxychloroquine 0 1
Atezolizumab + Cobimetinib + Nab-paclitaxel Atezolizumab Cobimetinib Nab-paclitaxel 0 1
Atezolizumab + Cobimetinib + Niraparib Atezolizumab Cobimetinib Niraparib 0 1
Atezolizumab + Cobimetinib + Paclitaxel Atezolizumab Cobimetinib Paclitaxel 0 1
Atezolizumab + Cobimetinib + Varlilumab Atezolizumab Cobimetinib Varlilumab 0 1
Atezolizumab + Cobimetinib + Vemurafenib Atezolizumab Cobimetinib Vemurafenib 5 7
Belvarafenib + Cobimetinib Belvarafenib Cobimetinib 5 1
Belvarafenib + Cobimetinib + Nivolumab Belvarafenib Cobimetinib Nivolumab 0 1
BI 853520 + Cobimetinib BI 853520 Cobimetinib 0 1
Calaspargase pegol-mknl + Cobimetinib Calaspargase pegol-mknl Cobimetinib 0 1
Ceritinib + Cobimetinib Ceritinib Cobimetinib 0 0
Cobimetinib Cobimetinib 88 12
Cobimetinib + Crizotinib Cobimetinib Crizotinib 0 0
Cobimetinib + Dexamethasone + Ixazomib + Pomalidomide Cobimetinib Dexamethasone Ixazomib Pomalidomide 0 1
Cobimetinib + Duligotuzumab Cobimetinib Duligotuzumab 0 1
Cobimetinib + Enasidenib Cobimetinib Enasidenib 0 1
Cobimetinib + Gemcitabine + Nab-paclitaxel Cobimetinib Gemcitabine Nab-paclitaxel 1 0
Cobimetinib + Ipatasertib Cobimetinib Ipatasertib 0 1
Cobimetinib + Ipilimumab + Nivolumab Cobimetinib Ipilimumab Nivolumab 0 1
Cobimetinib + LY3022855 + Vemurafenib Cobimetinib LY3022855 Vemurafenib 0 1
Cobimetinib + Nab-paclitaxel Cobimetinib Nab-paclitaxel 0 0
Cobimetinib + Niraparib Cobimetinib Niraparib 0 1
Cobimetinib + Onartuzumab Cobimetinib Onartuzumab 0 1
Cobimetinib + Onartuzumab + Vemurafenib Cobimetinib Onartuzumab Vemurafenib 0 1
Cobimetinib + Paclitaxel Cobimetinib Paclitaxel 0 1
Cobimetinib + Pembrolizumab + Vemurafenib Cobimetinib Pembrolizumab Vemurafenib 2 1
Cobimetinib + Pictilisib Cobimetinib Pictilisib 0 1
Cobimetinib + Ravoxertinib Cobimetinib Ravoxertinib 0 0
Cobimetinib + RGT-018 Cobimetinib RGT-018 0 0
Cobimetinib + RMC-4630 Cobimetinib RMC-4630 0 1
Cobimetinib + Selumetinib Cobimetinib Selumetinib 0 0
Cobimetinib + UNC2025 Cobimetinib UNC2025 1 0
Cobimetinib + Vemurafenib Cobimetinib Vemurafenib 52 16
Cobimetinib + Vemurafenib + XL888 Cobimetinib Vemurafenib XL888 0 1
Cobimetinib + Venetoclax Cobimetinib Venetoclax 0 1
Cobimetinib + VS-4718 Cobimetinib VS-4718 0 0


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