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Drug Detail
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| Drug Name | RG7112 |
| Trade Name | |
| Synonyms | RO5045337|RO-5045337 |
| Drug Descriptions |
RG7112 (RO5045337) binds to the p53-binding region of MDM2 and inhibits MDM2-p53 interaction, resulting in activation of p53 signaling, and decreased tumor cell growth (PMID: 24900694, PMID: 23400593, PMID: 31493899). |
| DrugClasses | MDM2 Inhibitor 23 |
| CAS Registry Number | 939981-39-2 |
| NCIT ID | C91724 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Doxorubicin + RG7112 | Doxorubicin RG7112 | 1 | 0 |
| Nutlin-3a + RG7112 | Nutlin-3a RG7112 | 0 | 0 |
| RG7112 | RG7112 | 1 | 0 |
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