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Drug Name | Nutlin-3a |
Trade Name | |
Synonyms | Nutlin|Nutlin-3 |
Drug Descriptions |
Nutlin-3a is an MDM2 inhibitor that activates p53, potentially resulting in induction of apoptosis and senescence in tumor cells (PMID: 18451145, PMID: 32653500). |
DrugClasses | MDM2 Inhibitor 23 |
CAS Registry Number | 548472-68-0 |
NCIT ID | C74594 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Carboplatin + Nutlin-3a | Carboplatin Nutlin-3a | 1 | 0 |
CCT007093 + Nutlin-3a | CCT007093 Nutlin-3a | 0 | 0 |
Cisplatin + Nutlin-3a | Cisplatin Nutlin-3a | 2 | 0 |
CTX-1 + Nutlin-3a | CTX-1 Nutlin-3a | 2 | 0 |
Doxorubicin + Nutlin-3a | Doxorubicin Nutlin-3a | 4 | 0 |
Etoposide + Nutlin-3a | Etoposide Nutlin-3a | 2 | 0 |
GSK2830371 + Nutlin-3a | GSK2830371 Nutlin-3a | 0 | 0 |
Nutlin-3a | Nutlin-3a | 9 | 0 |
Nutlin-3a + Paclitaxel | Nutlin-3a Paclitaxel | 0 | 0 |
Nutlin-3a + RG7112 | Nutlin-3a RG7112 | 0 | 0 |