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Drug Name | Milademetan |
Trade Name | |
Synonyms | DS-3032b|Milademetan Tosylate|DS3032b|DS 3032b|RAIN-32 |
Drug Descriptions |
Milademetan binds to MDM2 and prevents binding to p53, resulting in activation of p53 signaling and increased tumor cell apoptosis (PMID: 29416773, PMID: 32651541). |
DrugClasses | MDM2 Inhibitor 23 |
CAS Registry Number | 1398569-75-9 |
NCIT ID | C107384 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Cytarabine + Milademetan | Cytarabine Milademetan | 0 | 1 |
Cytarabine + Milademetan + Venetoclax | Cytarabine Milademetan Venetoclax | 0 | 1 |
Fulvestrant + Milademetan | Fulvestrant Milademetan | 0 | 1 |
Milademetan | Milademetan | 0 | 5 |
Milademetan + Osimertinib | Milademetan Osimertinib | 0 | 0 |
Milademetan + Quizartinib | Milademetan Quizartinib | 0 | 1 |
Milademetan + Selpercatinib | Milademetan Selpercatinib | 0 | 0 |
Milademetan + Trametinib | Milademetan Trametinib | 0 | 0 |