RO6839921
Drug Detail
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| Drug Name | RO6839921 |
| Trade Name | |
| Synonyms | RO-6839921 |
| Drug Descriptions |
RO6839921 is a pegylated prodrug of idasanutlin that binds to MDM2 and inhibits its interaction with p53, preventing degradation of p53, thereby potentially resulting in restoration of wild-type p53 activity and apoptosis of tumor cells (PMID: 31734832, PMID: 32020437). |
| DrugClasses | MDM2 Inhibitor 23 |
| CAS Registry Number | NA |
| NCIT ID | C114980 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Cytarabine + RO6839921 | Cytarabine RO6839921 | 1 | 0 |
| Pegylated liposomal doxorubicin + RO6839921 | Pegylated liposomal doxorubicin RO6839921 | 1 | 0 |
| RO6839921 | RO6839921 | 1 | 1 |
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