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Drug Name | Serdemetan |
Trade Name | |
Synonyms | JNJ-26854165|JNJ 26854165 |
Drug Descriptions |
Serdemetan (JNJ-26854165) is a small molecule that regulates ABCA1 expression and inhibits cholesterol transport, resulting in activation of p53 and increased cell death in Tp53 wild-type and mutant cells (PMID: 23820125, PMID: 27999193). |
DrugClasses | p53 Activator 11 |
CAS Registry Number | 881202-45-5 |
NCIT ID | C77904 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Imatinib + Serdemetan | Imatinib Serdemetan | 0 | 0 |
PD180970 + Serdemetan | PD180970 Serdemetan | 0 | 0 |
Serdemetan | Serdemetan | 2 | 0 |