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Drug Name Imatinib
Trade Name Gleevec
Synonyms CGP-57148B|STI571|Imatinib mesylate
Drug Descriptions

Gleevec (imatinib) is a multi-target inhibitor of c-Kit, Pdgfr, and Bcr-Abl (PMID: 12200353). Gleevec (imatinib) is FDA approved for c-KIT positive GIST and dermatofibrosarcoma protuberans, Philadelphia chromosome positive chronic myeloid leukemia, and FIP1L1-PDGFRA positive chronic eosinophilic leukemia (FDA.gov).

DrugClasses ABL Inhibitor (pan) 9 BCR-ABL Inhibitor 32 CSF1R Inhibitor 28 KIT Inhibitor 57 PDGFR Inhibitor (Pan) 30
CAS Registry Number 220127-57-1
NCIT ID C1687

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Afatinib + Imatinib Afatinib Imatinib 0 0
AIC-47 + Imatinib AIC-47 Imatinib 0 0
AKI603 + Imatinib AKI603 Imatinib 0 0
Asciminib + Imatinib Asciminib Imatinib 0 6
Asparaginase + Cyclophosphamide + Cytarabine + Dexamethasone + Imatinib + Methotrexate + Vincristine Sulfate Asparaginase Cyclophosphamide Cytarabine Dexamethasone Imatinib Methotrexate Vincristine Sulfate 0 0
Atezolizumab + Imatinib Atezolizumab Imatinib 0 1
Bemcentinib + Imatinib Bemcentinib Imatinib 0 0
BGT226 + Imatinib BGT226 Imatinib 0 0
BI-3802 + Imatinib BI-3802 Imatinib 0 0
Binimetinib + Imatinib Binimetinib Imatinib 12 2
Blinatumomab + Imatinib Blinatumomab Imatinib 0 1
Carboplatin + Imatinib + Paclitaxel Carboplatin Imatinib Paclitaxel 0 0
Cetuximab + Imatinib Cetuximab Imatinib 0 1
Copanlisib + Imatinib Copanlisib Imatinib 3 0
Cyclophosphamide + Cytarabine + Daunorubicin + Etoposide + Fludarabine + Imatinib + Melphalan + Mercaptopurine + Methotrexate + Pegaspargase + Rituximab + Vincristine Sulfate Cyclophosphamide Cytarabine Daunorubicin Etoposide Fludarabine Imatinib Melphalan Mercaptopurine Methotrexate Pegaspargase Rituximab Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Daunorubicin + Etoposide + Fludarabine + Imatinib + Melphalan + Mercaptopurine + Methotrexate + Pegaspargase + Vincristine Sulfate Cyclophosphamide Cytarabine Daunorubicin Etoposide Fludarabine Imatinib Melphalan Mercaptopurine Methotrexate Pegaspargase Vincristine Sulfate 0 1
Cyclophosphamide + Cytarabine + Dexamethasone + Doxorubicin + Imatinib + Methotrexate + Vincristine Sulfate Cyclophosphamide Cytarabine Dexamethasone Doxorubicin Imatinib Methotrexate Vincristine Sulfate 0 0
Cytarabine + Dexamethasone + Etoposide + Imatinib + Methotrexate + Vincristine Sulfate Cytarabine Dexamethasone Etoposide Imatinib Methotrexate Vincristine Sulfate 0 0
Cytarabine + Etoposide + Imatinib + Mercaptopurine + Methotrexate Cytarabine Etoposide Imatinib Mercaptopurine Methotrexate 0 1
Cytarabine + Imatinib + Methotrexate Cytarabine Imatinib Methotrexate 0 1
Dasatinib + Dexamethasone + Imatinib Dasatinib Dexamethasone Imatinib 0 0
Daunorubicin + Dexamethasone + Imatinib + Pegaspargase + Vincristine Sulfate Daunorubicin Dexamethasone Imatinib Pegaspargase Vincristine Sulfate 0 0
Daunorubicin + Imatinib + Prednisone + Vincristine Sulfate Daunorubicin Imatinib Prednisone Vincristine Sulfate 0 1
Dexamethasone + Imatinib + Vincristine Sulfate Dexamethasone Imatinib Vincristine Sulfate 0 1
Everolimus + Imatinib Everolimus Imatinib 0 1
G007-LK + Imatinib G007-LK Imatinib 1 0
Gefitinib + Imatinib Gefitinib Imatinib 0 0
GSK690693 + Imatinib GSK690693 Imatinib 0 0
Imatinib Imatinib 168 35
Imatinib + Infigratinib Imatinib Infigratinib 6 1
Imatinib + Inotuzumab ozogamicin Imatinib Inotuzumab ozogamicin 0 0
Imatinib + Interferon alpha-2b Imatinib Interferon alpha-2b 0 1
Imatinib + Ipilimumab Imatinib Ipilimumab 0 1
Imatinib + Letrozole Imatinib Letrozole 1 0
Imatinib + LY294002 Imatinib LY294002 1 0
Imatinib + MK2206 Imatinib MK2206 4 0
Imatinib + Nilotinib Imatinib Nilotinib 0 0
Imatinib + Osimertinib Imatinib Osimertinib 0 0
Imatinib + Pembrolizumab Imatinib Pembrolizumab 1 2
Imatinib + Pimitespib Imatinib Pimitespib 0 1
Imatinib + PKF118-310 Imatinib PKF118-310 1 0
Imatinib + PLX4720 Imatinib PLX4720 1 0
Imatinib + Ponatinib Imatinib Ponatinib 0 1
Imatinib + Prednisone + Vincristine Sulfate Imatinib Prednisone Vincristine Sulfate 0 1
Imatinib + Radiotherapy Imatinib Radiotherapy 0 0
Imatinib + Ruxolitinib Imatinib Ruxolitinib 0 1
Imatinib + Selinexor Imatinib Selinexor 0 1
Imatinib + Serdemetan Imatinib Serdemetan 0 0
Imatinib + SIAIS562055 Imatinib SIAIS562055 0 0
Imatinib + Spartalizumab Imatinib Spartalizumab 2 0
Imatinib + Torin 2 Imatinib Torin 2 0 0
Imatinib + unspecified PD-1 antibody Imatinib unspecified PD-1 antibody 0 0
Imatinib + unspecified PD-L1 antibody Imatinib unspecified PD-L1 antibody 0 0
Imatinib + Vactosertib Imatinib Vactosertib 0 0
Imatinib + Venetoclax Imatinib Venetoclax 0 0
Imatinib + XAV939 Imatinib XAV939 1 0
Imatinib + ZSTK474 Imatinib ZSTK474 0 0


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