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Drug Detail
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| Drug Name | CC-122 |
| Trade Name | |
| Synonyms | Avadomide |
| Drug Descriptions |
Avadomide (CC-122) is an immunomodulatory drug analog that targets Cereblon and promotes degradation of several proteins, including Ikaros and Aiolos, leading to decreased B-cell proliferation and decreased tumor angiogenesis (Blood Dec 2014, 124 (21) 3500). |
| DrugClasses | |
| CAS Registry Number | 1015474-32-4 |
| NCIT ID | C160786 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| CC-122 | CC-122 | 0 | 2 |
| CC-122 + Cyclophosphamide + Prednisone + Rituximab + Vincristine Sulfate | CC-122 Cyclophosphamide Prednisone Rituximab Vincristine Sulfate | 0 | 1 |
| CC-122 + Nivolumab | CC-122 Nivolumab | 0 | 2 |
| CC-122 + Onatasertib | CC-122 Onatasertib | 0 | 1 |
| CC-122 + Sorafenib | CC-122 Sorafenib | 0 | 1 |
| CC-122 + Spebrutinib | CC-122 Spebrutinib | 0 | 1 |
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