Pyrvinium
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| Drug Name | Pyrvinium |
| Trade Name | |
| Synonyms | Pyrvinium Pamoate |
| Drug Descriptions |
Pyrvinium blocks STAT3 and activates CK1-alpha, which leads to CTNNB1 degradation and inhibition of Wnt signaling thereby inducing apoptosis (PMID: 20890287, PMID: 32298693). |
| DrugClasses | CTNNB1 Inhibitor 27 STAT3 Inhibitor 26 |
| CAS Registry Number | 3546-41-6 |
| NCIT ID | C66499 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Pyrvinium | Pyrvinium | 1 | 1 |
| Pyrvinium + Vemurafenib | Pyrvinium Vemurafenib | 1 | 0 |
CKB BOOST