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Drug Name | IWR-1 |
Trade Name | |
Synonyms | IWR-1-endo |
Drug Descriptions |
IWR-1 selectively inhibits Wnt/beta-catenin mediated signaling by inhibiting tankyrase1/2, thus stabilizing Axin and stimulating beta-catenin degradation (PMID: 23621985, PMID: 31452704). |
DrugClasses | Tankyrase Inhibitor 11 |
CAS Registry Number | 1127442-82-3 |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Everolimus + IWR-1 | Everolimus IWR-1 | 0 | 0 |
IWR-1 | IWR-1 | 8 | 0 |