DZNeP
Drug Detail
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| Drug Name | DZNeP |
| Trade Name | |
| Synonyms | 3-Deazaneplanocin A |
| Drug Descriptions |
DZNeP (3-Deazaneplanocin A) inhibits S-adenosylhomocysteine hydrolase, resulting in depletion of EZH2 and inhibition of H3K27 methylation, which may promote apoptosis in cancer cells (PMID: 3790170, PMID: 19638619, PMID: 32508971). |
| DrugClasses | EZH2 inhibitor 20 |
| CAS Registry Number | 120964-45-6 |
| NCIT ID | NA |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| ACY-957 + DZNeP | ACY-957 DZNeP | 0 | 0 |
| DZNeP | DZNeP | 1 | 0 |
| DZNeP + MK2206 | DZNeP MK2206 | 0 | 0 |
| DZNeP + Radiotherapy | DZNeP Radiotherapy | 1 | 0 |
| DZNeP + Selumetinib | DZNeP Selumetinib | 0 | 0 |
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