Navicixizumab
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| Drug Name | Navicixizumab |
| Trade Name | |
| Synonyms | OMP-305B83|OMP 305B83|OMP305B83 |
| Drug Descriptions |
Navicixizumab (OMP-305B83) is a bispecific antibody that binds both DLL4 and VEGF, which inhibits NOTCH and VEGFR signaling and may prevent angiogenesis and tumor growth (PMID: 30229512). |
| DrugClasses | DLL4 Antibody 7 VEGF Antibody 15 |
| CAS Registry Number | 1638338-43-8 |
| NCIT ID | C119620 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Fluorouracil + Irinotecan + Leucovorin + Navicixizumab | Fluorouracil Irinotecan Leucovorin Navicixizumab | 0 | 1 |
| Irinotecan + Navicixizumab | Irinotecan Navicixizumab | 0 | 1 |
| Navicixizumab | Navicixizumab | 0 | 2 |
| Navicixizumab + Paclitaxel | Navicixizumab Paclitaxel | 0 | 2 |
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