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| Drug Name | Pinometostat |
| Trade Name | |
| Synonyms | EPZ-5676|EPZ5676 |
| Drug Descriptions |
Pinometostat (EPZ-5676) inhibits DOT1L histone methyltransferase activity, resulting in decreased growth of leukemia cells with MLL rearrangements (PMID: 23801631, PMID: 26645404, PMID: 29724899). |
| DrugClasses | DOT1L Inhibitor 3 |
| CAS Registry Number | 1380288-87-8 |
| NCIT ID | C103179 |
| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Azacitidine + Pinometostat | Azacitidine Pinometostat | 0 | 1 |
| Cytarabine + Daunorubicin + Pinometostat | Cytarabine Daunorubicin Pinometostat | 0 | 1 |
| Pinometostat | Pinometostat | 2 | 1 |