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Therapy Name Cytarabine + Daunorubicin + Pinometostat
Synonyms
Therapy Description

EPZ-5676 (Pinometostat) inhibits DOT1L histone methyltransferase activity, resulting in decreased growth of leukemia cells with MLL rearrangements (PMID: 23801631, PMID: 26645404).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Cytarabine Cytosar-U Ara-C Cytosar-U (cytarabine) is a cytidine analog that, when incorporated into DNA, inhibits DNA synthesis and repair (PMID: 32524309).
Daunorubicin Cerubidine Rubidomycin|daunomycin hydrochloride|rubomycin C|Acetyladriamycin Chemotherapy - Anthracycline 13 Cerubidine (daunorubicin) is an anthracycline, which inhibits DNA replication and repair. Cerubidine (daunorubicin) is FDA approved for AML and MLL (FDA.gov).
Pinometostat EPZ-5676|EPZ5676 DOT1L Inhibitor 3 Pinometostat (EPZ-5676) inhibits DOT1L histone methyltransferase activity, resulting in decreased growth of leukemia cells with MLL rearrangements (PMID: 23801631, PMID: 26645404, PMID: 29724899).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03724084 Phase Ib/II Cytarabine + Daunorubicin + Pinometostat Pinometostat With Standard Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia and MLL Gene Rearrangement Terminated USA 0


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