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Drug Name | TH-4000 |
Trade Name | |
Synonyms | PR610|Hypoxin|TRLX|Tarloxotinib bromide|Tarloxotinib |
Drug Descriptions |
TH-4000 (tarloxotinib) is a prodrug that is converted to an irreversible Egfr/Erbb2 (Her2)/Erbb4 inhibitor under hypoxia, potentially resulting in inhibition of tumor cell growth (PMID: 33355298). |
DrugClasses | EGFR Inhibitor (Pan) 62 HER2 Inhibitor 42 |
CAS Registry Number | 1636180-98-7 |
NCIT ID | C152514 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Sotorasib + TH-4000 | Sotorasib TH-4000 | 0 | 1 |
TH-4000 | TH-4000 | 0 | 4 |