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| Drug Name | Sotorasib |
| Trade Name | Lumakras |
| Synonyms | AMG 510|AMG510|AMG-510|Lumykras |
| Drug Descriptions |
Lumakras (sotorasib) is small molecule inhibitor that selectively targets KRAS G12C and inhibits downstream signaling, which may lead to growth inhibition of tumors harboring KRAS G12C (PMID: 31666701). Lumakras (sotorasib) is FDA approved for use in patients with locally advanced or metastatic non-small cell lung cancer harboring KRAS G12C who have received one or more prior therapy, and in combination with Vectibix (panitumumab) in patients with metastatic colorectal cancer harboring KRAS G12C who have received chemotherapy (FDA.gov). |
| DrugClasses | KRAS G12C inhibitor 34 |
| CAS Registry Number | 2252403-56-6 |
| NCIT ID | C154287 |
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